Storing the results of a research project in case they may later turn out to be useful would seem like sensible practice to most scientists around the world.
But most researchers would not expect to discover that their previous work suddenly had the potential to tackle the worst pandemic the world has seen in 100 years.
This is exactly what has happened to a team of researchers based in the Netherlands, who discovered that an antibody sitting in their laboratory freezer can block the Sars-CoV-2 coronavirus, which causes Covid-19.
Berend-Jan Bosch, associate professor of virology at Utrecht University, described how he and fellow researchers had been working two years ago on identifying antibodies that had the potential to tackle other coronaviruses, such as the one that caused Sars.
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Despite finding dozens of such antibodies, interest in Sars was 鈥渨aning鈥 so they decided to store them in the freezer.
Then, when the Covid-19 crisis began to take hold in January, Dr Bosch said he 鈥渞ealised that we might have valuable antibodies in the freezer鈥 that could tackle the new coronavirus.
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They 鈥渞apidly tested鈥 the antibodies and 鈥渨ere excited to see that four of them actually showed good reactivity against the new coronavirus鈥. Further work then established that one antibody could actually block Sars-CoV-2 鈥 as well as Sars-Cov, the coronavirus that causes Sars 鈭 from infecting cells in a lab environment.
The research, carried out in partnership with other institutions including Erasmus University Medical Centre, was聽聽and may have the potential to lead to anti-viral treatments to tackle Covid-19.
Dr Bosch, speaking during an online press conference to discuss the discovery, is now involved in negotiations with the pharmaceutical industry about how such treatments could be developed. He said testing on patients could be possible in six months under the most optimistic scenario.
鈥淥ur antibody is the first step, and an encouraging step, in the development of such an anti-viral agent. I have to stress that many steps have to be taken,鈥 he said.
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The Dutch researcher, one of the world鈥檚 most cited coronavirologists聽according to a聽糖心Vlog聽data analysis, said that although the workload of the past few months had been 鈥渙verwhelming鈥, it had been 鈥渧ery satisfying to be a little bit of help to mitigate this crisis鈥.
He said he had also been 鈥渞eally encouraged鈥 by the huge number of researchers around the world who were becoming involved in work to tackle the coronavirus.
鈥淏efore this crisis, there were not too many coronavirologists鈥ut now more and more virologists, but also people from other disciplines, are stepping in and want to tackle this virus. So that is a really good thing.鈥
Asked if there was a danger of duplication of effort with so many scientists now involved in different collaborations in the race for treatments and a vaccine, he said he did not see this as a concern.
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鈥淭here are independent groups working next to each other. They may do similar work at the same time, but I don鈥檛 see that as a real problem because you get different insights. You will always add to the knowledge that we collectively create and generate to tackle this virus.鈥
Dr Bosch also urged governments to continue to draw on expertise from across disciplines as they search for answers to the crisis: 鈥淚 think governments [have engaged] scientists from different disciplines: the epidemiologists, the molecular biologists, virologists, medical [experts]鈥nd I think that is the way it should be, because we have to recruit all knowledge on different aspects of this whole pandemic.鈥
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